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. 2024 Mar 25;115(6):1763–1777. doi: 10.1111/cas.16154

FIGURE 5.

FIGURE 5

Immunological characteristics of the tumor microenvironment in the proximal proliferative (PP) subtype of lung adenocarcinoma (LUAD). (A) Suppressed pathways in the PP subtype were identified by Gene Set Enrichment Analysis using the Gene Ontology gene set. (B) Proportion of CD86+ dendritic cells (DCs) in each molecular subtype of LUAD. (C) Immunogram (activated DC) of each molecular subtype of LUAD. (D) Lactate content in each molecular subtype of LUAD. (E) Expression of glucose metabolism‐related genes (TPI1, LDHA, and GLUT1) in each molecular subtype of LUAD. (F) Expression of GLUT1 determined by single‐cell RNA sequencing in multiple cell types within tumor and nontumor (NT) sites. Dot plot heatmap showing average scaled expression (color) and percentage of cells (dot size) expressing each gene. EC, enterochromaffin cell; NK, natural killer; ns, not significant; PI, proximal inflammatory; TPM, transcripts per million; TRU, terminal respiratory unit; UMAP, uniform manifold approximation and projection.