TABLE 1.
Summary of clinicopathologic, immunologic, and multi‐omics characteristics of lung adenocarcinoma subtypes.
| Molecular subtype | |||
|---|---|---|---|
| PI | PP | TRU | |
| Clinicopathologic features | |||
| Prognosis | Favorable | Poor | Favorable |
| Stage | High | High | Low |
| Differentiation | Poor | Moderate | Well |
| Lymphatic invasion | High | High | Low |
| Vascular invasion | High | Moderate | Low |
| Lymph node metastasis | High | Moderate | Low |
| Spread through air spaces | High | Moderate | Low |
| Tertiary lymphoid structures | High | Moderate | Low |
| TIL profile | |||
| CD8+ T cells | High | Moderate | Low |
| B cells | High | Moderate | Low |
| NK cells | High | Low | Low |
| pDC | High | Moderate | Low |
| PD‐1+ CD4 | High | Moderate | Low |
| Activation status of DC | High | Low | High |
| Genomic mutations | |||
| EGFR | Low | Low | High |
| TP53 | Moderate | High | Low |
| Glycolysis‐related molecules | |||
| GLUT1 expression | Moderate | High | Low |
| LDHA expression | Moderate | High | Low |
| Lactate | Low | High | Low |
Abbreviations: DC, dendritic cell; EGFR, epidermal growth factor receptor; GLUT1, glucose transporter 1; LDHA, lactate dehydrogenase A; NK, natural killer; PD‐1, programmed cell death 1; PI, proximal inflammatory; PP, proximal proliferative; TIL, tumor‐infiltrating leukocyte; TRU, terminal respiratory unit.