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. 2024 Mar 13;30(11):2317–2332. doi: 10.1158/1078-0432.CCR-23-3632

Figure 4.

Figure 4. A balanced “ménage à trois” between the tumor (brown), lymphocytes (blue), and myeloid cells (purple) is crucial to achieve tumor control posttreatment and ensure the establishment of an efficient antitumor immunosurveillance in the long term. Reaching a disproportionate overrepresentation of the myeloid compartment at some point of the treatment journey is detrimental and feeds a vicious cycle in which innate and adaptive immune abilities are inhibited, a phenomenon that is complex to turn over.

A balanced “ménage à trois” between the tumor (brown), lymphocytes (blue), and myeloid cells (purple) is crucial to achieve tumor control posttreatment and ensure the establishment of an efficient antitumor immunosurveillance in the long term. Reaching a disproportionate overrepresentation of the myeloid compartment at some point of the treatment journey is detrimental and feeds a vicious cycle in which innate and adaptive immune abilities are inhibited, a phenomenon that is complex to turn over.