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. 2024 Feb 22;14(6):1048–1063. doi: 10.1158/2159-8290.CD-23-1060

Figure 5.

Figure 5. CSM and FLS estimate ctDNA clearance status, identifying patients with durable response to pembrolizumab. The log odds of cancer were computed using a logistic regression model with CSM and FLS as independent variables. A threshold of below −1.754 was determined to identify patients with clearance. A, By this criterion, 11 patients cleared ctDNA based on cfMeDIP-seq, of which 9 also had undetectable ctDNA based on CMC from targeted deep sequencing. B, Patients with clearance demonstrated persistently low cfMeDIP-seq scores. The two patients with clearance by CMC but not cfMeDIP-seq (INS-A-019 and INS-D-012) both had low cfMeDIP-seq scores near the clearance threshold. C, The clinical course and radiologic size of index tumors of all 13 patients with clearance by either method are shown. Vertical lines show the median and maximum PFS of patients within each cohort. D, Patients meeting the cfMeDIP-seq clearance criteria demonstrated strikingly favorable PFS and OS.

CSM and FLS estimate ctDNA clearance status, identifying patients with durable response to pembrolizumab. The log odds of cancer were computed using a logistic regression model with CSM and FLS as independent variables. A threshold of below −1.754 was determined to identify patients with clearance. A, By this criterion, 11 patients cleared ctDNA based on cfMeDIP-seq, of which 9 also had undetectable ctDNA based on CMC from targeted deep sequencing. B, Patients with clearance demonstrated persistently low cfMeDIP-seq scores. The two patients with clearance by CMC but not cfMeDIP-seq (INS-A-019 and INS-D-012) both had low cfMeDIP-seq scores near the clearance threshold. C, The clinical course and radiologic size of index tumors of all 13 patients with clearance by either method are shown. Vertical lines show the median and maximum PFS of patients within each cohort. D, Patients meeting the cfMeDIP-seq clearance criteria demonstrated strikingly favorable PFS and OS.