Fig. 1.

P4HA3 expression in CRC was analyzed using TCGA COAD-READ and GEO databases, and the correlation of P4HA3 with clinicopathological features and its prognostic value were assessed using TCGA COAD-READ. (A) P4HA3 expression in unpaired (left) and paired samples (right) in TCGA. (B) P4HA3 expression between normal and tumor samples in the GSE9348 and GSE21815 datasets. (C–G) Differential expression of P4HA3 in TNM staging, pathologic staging, and perineural invasion. Survival curves showing (H) OS, (I) DSS, and (J) PFI between patients with low and high P4HA3 expression. (K) P4HA3 diagnostic ROC curves for CRC models. (L) The Forest plot representing a one-way Cox univariate regression analysis.