Table 3.
circ_RNAs in cancer associated drug resistance
| Circ_RNA | Target | Chemotherapy Drug | Correlation |
|---|---|---|---|
| circ_0007385 | HMGB1 | Cisplatin | Circ_0007385 functions as a competitive endogenous RNA, exerting inhibitory effects on the malignant behaviors and cisplatin resistance of non-small cell lung cancer cells by sequestering miR-519d-3p. |
| circ 0008253 | TGF-β | Oxaliplatin | Exosomes derived from macrophages control oxaliplatin resistance in gastric cancer cells by encapsulating circ 0008253. |
| circ_0076305 | ABCC1 | Cisplatin | Circular RNA circ_0076305 enhances cisplatin (DDP) resistance in non-small cell lung cancer cells by modulating ABCC1 via miR-186-5p regulation. |
| circ-ZEB1 | N/A | Oxaliplatin and 5-fluorouracil (5-FU) | Circular RNA circ-ZEB1 modulates epithelial-mesenchymal transition and chemotherapy resistance in colorectal cancer by interacting with miR-200c-5p. |
| circRNA_103615 | ABCC1 | Cisplatin | Circular RNA circRNA_103615 plays a role in both the advancement of tumors and the development of cisplatin resistance in non-small cell lung cancer (NSCLC) by controlling ABCB1. |
| circ_0008928 | HK2 | Cisplatin | The biomarker circ_0008928 derived from serum exosomes modulates cisplatin sensitivity, tumor progression, and glycolysis metabolism through the miR-488/HK2 axis in cisplatin-resistant non-small cell lung carcinoma. |
| circ-RNF121 | SOX4 | Cisplatin | Circular RNA circ-RNF121 plays a role in the resistance of non-small cell lung cancer cells to cisplatin (DDP) by modulating the miR-646/SOX4 axis. |
| circ-PIP5K1A | N/A | Cisplatin | The mechanism involving the circ-PIP5K1A/miR-942-5p/NFIB axis in cisplatin resistance in ovarian cancer elucidated through imaging and molecular diagnostics. |
| hsa_circRNA_103809 | GOT1 | Cisplatin | A newly discovered circular RNA, hsa_circRNA_103809, orchestrates cisplatin resistance in non-small cell lung cancer (NSCLC) through the miR-377-3p/GOT1 pathway. |
| circ_0082182 | NFIB | Oxaliplatin | Circular RNA circ_0082182 enhances the expression of NFIB by sequestering miR-326, thereby promoting oxaliplatin resistance and the malignant progression of colorectal cancer cells. |
| circ-PRMT5 | REV3L | Cisplatin | Through the miR-4458/REV3L axis, circular RNA PRMT5 imparts cisplatin resistance in non-small-cell lung cancer. |
| circAKT3 | STAT3 | Cisplatin | In lung cancer cells, CircAKT3 suppresses glycolytic balance by controlling miR-516b-5p/STAT3, leading to the inhibition of cisplatin sensitivity. |
| circ-LDLRAD3 | SOX5 | Cisplatin | Reducing the expression of circ-LDLRAD3 diminishes cisplatin chemoresistance and hinders the progression of cisplatin-resistant gastric cancer by inhibiting SOX5 through the enrichment of miR-588. |
| circRNA-FOXO3 | Foxo3 | Cisplatin | Through the miR-543/Foxo3 axis, circular RNA FOXO3 promotes glycolysis and enhances cisplatin sensitivity in lung cancer cells. |
| hsa_circ_0014235 | CDK4 | Cisplatin | Exosomes transfer hsa_circ_0014235, fostering chemoresistance to DDP and exacerbating the progression of non-small cell lung cancer by orchestrating the miR-520a-5p/CDK4 pathway. |
| hsa_circ_0096157 | N/A | Cisplatin | Circular RNA hsa_circ_0096157 plays a role in cisplatin resistance by promoting proliferation, facilitating cell cycle progression, and suppressing apoptosis in non-small-cell lung carcinoma cells. |
| circRNA_100565 | ADAM28 | Cisplatin | Circular RNA circRNA_100565 contributes to cisplatin resistance in NSCLC cells by modulating proliferation, apoptosis, and autophagy through the miR-337-3p/ADAM28 axis. |
| circ_0076305 | ABCC1 | Cisplatin | Circular RNA circ_0076305 enhances resistance to cisplatin (DDP) in non-small cell lung cancer cells by modulating ABCC1 through miR-186-5p. |
| circ_PIP5K1A | ROCK1 | Cisplatin | Circular RNA Circ_PIP5K1A governs cisplatin resistance and malignant progression in non-small cell lung cancer cells and a xenograft murine model by relying on the miR-493-5p/ROCK1 axis. |
| hsa_circ_0085131 | ATG7 | Cisplatin | Circular RNA hsa_circ_0085131 participates in the cisplatin resistance of non-small-cell lung cancer cells by modulating autophagy. |
| circ-ABCB10 | AK4 | Cisplatin | Reducing the expression of circ-ABCB10 enhances the sensitivity of lung cancer cells to cisplatin through the miR-556-3p/AK4 axis. |
| circ-AnnexinA7 | Cyclin D1 | Cisplatin | Circular RNA-AnnexinA7 expedites cisplatin resistance in non-small cell lung cancer by manipulating microRNA-545-3p to mediate Cyclin D1. |
| Circ-ERBB2 | PTEN | 5-FU | Downregulation of Circ-ERBB2 renders colorectal cancer cells more susceptible to 5-FU by modulating the miR-181a-5p/PTEN/Akt pathway. |
| circ_0000079 | FXR1 | Cisplatin | Circ_0000079 acts as a decoy for the RNA-binding protein FXR1, disrupting the formation of the FXR1/PRCKI complex and diminishing their role in cell invasion and drug resistance in non-small cell lung cancer (NSCLC). |
| circ_0001821 | GRK5 | Paclitaxel | Suppression of Circ_0001821 through knockdown inhibits the growth, metastasis, and taxane resistance of non-small-cell lung cancer cells by modulating the miR-526b-5p/GRK5 axis. |
| circ_ZFR | KPNA4 | Paclitaxel | Circular RNA Circ_ZFR plays a role in both paclitaxel resistance and the progression of non-small cell lung cancer by elevating KPNA4 levels through the sequestration of miR-195-5p. |
| circANKRD17 | FOXR2 | Paclitaxel | Circular RNA circANKRD17 (also known as hsa_circ_0007883) induces paclitaxel resistance in ovarian cancer by interacting with FUS to stabilize FOXR2. |
| circ_0011292 | TRIM65 | Paclitaxel | Circular RNA Circ_0011292 boosts paclitaxel resistance in non-small cell lung cancer by modulating the miR-379-5p/TRIM65 axis. |
| circ_0010235 | E2F7 | Cisplatin | Circular RNA circ_0010235 imparts cisplatin resistance in lung cancer by elevating E2F7 levels through sequestering miR-379-5p. |
| hsa_circ_0002874 | MDM2/P53 pathway | Paclitaxel | The upregulation of hsa_circ_0002874 induces resistance in non-small cell lung cancer to paclitaxel by influencing the miR-1273f/MDM2/p53 pathway. |
| Circ_0001667 | N/A | Adriamycin | Circular RNA Circ_0001667 enhances resistance to Adriamycin and fosters malignant progression by targeting the miR-193a-5p/Rap2A molecular axis in breast cancer. |
| Circ_0078607 | N/A | Platinum | Circular RNA Circ_0078607 enhances sensitivity to platinum drugs through the miR-196b-5p/GAS7 axis in ovarian cancer. |
| hsa_circ_0030998 | N/A | Paclitaxel | A recently discovered circular RNA, hsa_circ_0030998, hinders tumorigenesis and Taxol resistance in lung cancer by acting as a sponge for miR-558. |
| circ_0002483 | GRB2, FOXO1, and FOXO3 | Taxol | Circular RNA hsa_circ_0002483 impedes the progression and improves Taxol sensitivity in non-small cell lung cancer by targeting miR-182-5p. |
| circ_0014130 | YAP1 | Docetaxel | Inhibiting circ_0014130 mitigated drug resistance and malignant behaviors in non-small cell lung cancer (NSCLC) cells with acquired docetaxel resistance by modulating the miR-545-3p-YAP1 axis. |
| circPOFUT1 | N/A | Cisplatin | Circular RNA circPOFUT1 amplifies malignant characteristics and chemoresistance associated with autophagy by capturing miR-488-3p to activate the PLAG1-ATG12 axis in gastric cancer. |
| circ_0003998 | CORO1C | Docetaxel | Circular RNA circ_0003998 governs the progression and docetaxel sensitivity of non-small cell lung cancer cells resistant to DTX through the miR-136-5p/CORO1C axis. |
| hsa_circ_0005909 | SOX4 | Adriamycin | Circular RNA hsa_circ_0005909 serves as a prognostic indicator for poor outcomes and facilitates the growth, metastasis, and drug resistance of non-small-cell lung cancer through the miRNA-338-3p/SOX4 pathway. |
| circRBM33 | N/A | Osimertinib | Circular RNA circRBM33 stimulates migration and invasion while mediating resistance to osimertinib in a non-small cell lung cancer cell line. |
| circRNA_0067717 | p53 | Paclitaxel | Circular RNA circRNA_0067717 induces resistance to paclitaxel in nasopharyngeal carcinoma by serving as a scaffold for the interaction between TRIM41 and p53. |
| circASK1 | N/A | Gefitinib | A recently identified protein encoded by circASK1 alleviates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis. |
| circSETD3 | ABCG2 | Gefitinib | Circular RNA circRNA_103615 plays a role in both the advancement of tumors and the development of cisplatin resistance in non-small cell lung cancer (NSCLC) through the regulation of ABCB1. |
| CircIFNGR2 | KRAS | Cetuximab | Circular RNA CircIFNGR2 promotes the proliferation and migration of colorectal cancer (CRC) and induces cetuximab resistance by indirectly targeting KRAS through sequestering MiR-30b. |
| circANKRD28 | N/A | Cisplatin | Circular RNA circANKRD28 suppresses cisplatin resistance in non-small-cell lung cancer by modulating the miR-221-3p/SOCS3 axis. |
| circSnx12 | N/A | Cisplatin | Circular RNA circSnx12 imparts cisplatin chemoresistance to ovarian cancer by suppressing ferroptosis through the miR-194-5p/SLC7A11 axis. |
| circRNA_102481 | ROR1 | EGFR-TKIs | Exosomal circRNA_102481, derived from tumors, contributes to resistance against EGFR-TKIs through the miR-30a-5p/ROR1 axis in non-small cell lung cancer. |