Figure 1:

Schematic illustration of the proposed hypothesis on the advantages of APC over ADC. Both constructs bind to the cell surface antigen (1) and can be internalized via receptor mediated endocytosis⁹ (2). The cytotoxic payload is released in the cytosol (3) which induces cell death (4). APCs have high and tunable DAR and showed improved efficacy (IC₅₀) in compared to commercially available ADC. The inset figure represents the comparative cytotoxicity of APC and ADC in SKBR3 (HER2+) cells.