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Synthesis and cytotoxicity studies of HER2/APC with SN38 (7-ethyl-10-hydroxycampothecin) drug. (a) Total synthetic scheme of polymer P3 and SN38 conjugation reaction. (b) UV-vis absorbance of drug conjugated polymer. The absorbance peak at 370 nm confirms the conjugation of drug to the polymer. (c) SN38 HER2/APC construct. (d) Cytotoxicity evaluation of HER2/SN38high and IgG/SN38high in SKOV3 (HER2+) cell.
