Figure 2. Primary and Sensitivity Analysis Model Estimates of Study Group Effects on the Primary 24-Week Outcome Measure of FACT-L Scores.

FACT-L indicates Functional Assessment of Cancer Therapy–Lung; GEE, generalized estimating equation. Points indicate model estimates of the mean between-group difference in FACT-L scores at week 24. All estimates are adjusted for study site and cancer type. Whiskers extend to the lower 1-sided 95% confidence limit for each estimate. Comparing the lower 1-sided 95% confidence limit with the noninferiority margin corresponds to the primary 1-sided 5% significance level test for noninferiority. Sensitivity analysis methods are described in eAppendix 2 in Supplement 3.