Reagent or Resource	Source/Company	Cat. No.
Antibodies
GLUT4	Cell Signaling Technology	#2213
β-actin	Thermo Fisher Scientific	#AM4302
Pref1	Abcam	ab119930
CD63	Abclonal	A19023
F4/80	Abcam	ab6640
FABP4	Cell Signaling Technology	#50699
Anti-Mouse IgG (Alexa Fluor 488 conjugated)	Cell Signaling Technology	#4408
Anti-Rabbit IgG (Alexa Fluor 488 conjugated)	Thermo Fisher Scientific	#A-11034
Anti-Rabbit IgG (Alexa Fluor 568 conjugated)	Thermo Fisher Scientific	#A-1101
Anti-Goat IgG (Alexa Fluor 594 conjugated)	Thermo Fisher Scientific	#A-11058
FITC anti-mouse F4/80 antibody	BioLegend	123107
PE anti-human CD68 Antibody	BioLegend	333801
TruStainFcX (anti-mouse CD16/32)	BioLegend	156603
TruStainFcX (anti-human CD16/32)	BioLegend	422301
HRP-conjugated Anti-Mouse IgG antibody	Sigma-Aldrich	#A9044
HRP-conjugated Anti-Rabbit IgG antibody	Sigma-Aldrich	#A9169
Chemicals, peptides, and recombinant proteins
Ampicillin	Sigma-Aldrich	A0166
DMEM	Gibco	#11995073
Insulin solution from bovine pancreas	Sigma-Aldrich	I0516
Bovine calf serum	ATCC	ATCC30-2030
Penicillin-Streptomycin solution	Gibco	#15140122
FBS	Gibco	#10082147
Dexamethasone	Sigma-Aldrich	D1756
IBMX	Sigma-Aldrich	I5879
Minimum Essential Medium	ATCC	30-2003
RPMI 1640	Gibco	#A1049101
mouse M-CSF1 recombinant protein	Thermo Fisher Scientific	#PMC2044
DMEM	ATCC	30-2002
Oil Red O	Sigma-Aldrich	# O1391
Mayer’s Hematoxylin	Thermo Fisher Scientific	# 72804
Eosin Stain Solution	Himedia	#S007
Lipofectamine RNAiMAX transfection reagent	Invitrogen	#13778030
Invivofectamine 3.0 reagent	Invitrogen	IVF3005
Lipofectamine LTX reagent with PLUS reagent	Invitrogen	#15338100
NP40 Cell lysis buffer	Invitrogen	#FNN0021
Halt Protease and Phosphatase Inhibitor Cocktail	Invitrogen	#78441
Rodent Diet With 10 kcal% Fat and Carbohydrate	Research Diet	D12450K
Rodent Diet With 60 kcal% Fat	Research Diet	D12492
TRIzol	Invitrogen	15596018
iScript cDNA Synthesis Kit	Bio-Rad	#1708891
PowerUpTM SYBRTM Green Master Mix	Applied Biosystems	A25742
ClarityTM Western ECL Substrate	Bio-Rad	#1705061
TaqManTM Multiplex Master Mix	Applied Biosystems	#4461881
PVDF membranes	Bio-Rad	1620177
collagenase type I	Sigma-Aldrich	SCR103
Tissue Freezing Medium	Leica Biosystems	14020108926
Rapid Detection of Firefly Luciferase Activity	Promega	E1500
VECTASHIELD Antifade Mounting Medium with DAPI	Vector Laboratories	H-1200
Vybrant DiO Cell-Labeling Solution	Invitrogen	V22886
T4 DNA Ligase	NEB	# M0202S
XbaI	NEB	#R0145S
Sall	NEB	#R3138S
Opti-MEM	GIBCO	# 31985-062
Kreb’s Ringer Bicarbonate Buffer	HiMedia	#TL-1097
RNase A	Thermo Scientific	EN0531
ExoQuick-TC ULTRA	SBI	EXOTC50A-1
ExoQuick ULTRA	SBI	EQULTRA-20A-1
Total exosome RNA and protein isolation kit	Invitrogen	#4478545
mirVana miRNA Isolation Kit	Invitrogen	AM1560
TaqMan MicroRNA Reverse Transcription Kit	Applied Biosystems	4366596
BCA Protein Assay Kit	Thermo Fisher Scientific	#23225
mouse insulin ELISA kits	Elabscience	E-EL-M1382
QuickChange Lightning Multi Site-Directed Mutagenesis Kit	Agilent	#210515
Glucose Uptake Cell-Based Assay Kit	Cayman	#600470
GeneJET Gel Extraction Kit	Thermo Fisher Scientific	K0691
Cell lines
3T3-L1	ATCC	ATCCL-173
C2C12	ATCC	CRL-1772
RAW264.7	National Centre for Cell Science, Pune	N/A
Mouse
C57BL/6	NIPER SAS Nagar	N/A
Oligonucleotides
miRIDIAN miR-210-3p mimic	Dharmacon	cat. no. #C-310570-05-0005 accession no.: MIMAT0000658
miRIDIAN miR-210-3p inhibitor	Dharmacon	cat. no. #IH-310570-07-0005, accession no.:MIMAT0000267
miRIDIAN miRNA hairpin mimic negative control	Dharmacon	cat. no. #CN-001000-01-05 accession no.:MIMAT0000039
miRIDIAN miRNA hairpin inhibitor negative control	Dharmacon	cat. no. #IN-001005-01-05, accession no.: MIMAT0000039
miRCURY miR-210-3p mimic LNA (5′FAM)	Qiagen	GeneGlobe ID: YM00470861-AGB; cat.no. 339174
miRCURY control mimic LNA	Qiagen	GeneGlobe ID: YM00479902-AGA; cat. no. 339174
miRCURY miR-210-3p mimic LNA	Qiagen	GeneGlobe ID: YM00470861-AGA, cat. no. 339174
miRCURY mmu-miR-210-3p Inhibitor LNA (3′FAM)	Qiagen	GeneGlobe ID: YI04103147-DDC; catalog no. 339131
miRCURY LNA miRNA Inhibitor Control	Qiagen	GeneGlobe ID: YI00199006-DDA; cat no. 339136
Primers for qRT-PCR: See Table S1
Recombinant DNA
pGL3-MYB-3′UTR	Addgene	#25798 RRID: Addgene_25798
Software
ImageJ	Schneider et al. (48)	https://imagej.nih.gov/ij/
GraphPad Prism 9	GraphPad Software	https://www.graphpad.com/
RNAhybrid	Rehmsmeier et al. (49)	https://bibiserv.cebitec.uni-bielefeld.de/rnahybrid;jsessionid=57c94cffe9f53afa1dc320ba3c06
NTA 3.3	Malvern Panalytical	https://www.malvernpanalytical.com/en/support/product-support/software/nanosight-nta-software-update-v3-3
LasX	Leica Microsystem	https://www.leica-microsystems.com/products/microscope-software/p/leica-las-x-ls/?nlc=20221205-SFDC-015771&utm_source=google&utm_medium=cpc&utm_campaign=23-AP-ALL-L3-GLMS-GOOG-PP-India-General-Search&utm_content=text_ad&utm_term=leica%20lasx&gad_source=1&gclid=CjwKCAiA98WrBhAYEiwA2WvhOl1xYTWBcJdjT2GCRz-AEOFnU0_-_Z_s554tEkPXdZyioJxb-IBRkRoC_uYQAvD_BwE
Zen Black	Carl Zeiss	https://www.micro-shop.zeiss.com/en/de/softwarefinder/software-categories/zen-black/zen-black-system/