Table 1.

Overview of the primary and secondary outcomes and the assessment method at each time interval

Outcome	Method	A1 Baseline	A2, 3, 4 1, 3, 6 months	A5 12 months	A6 18 months	A7 24 months	A8 36 months
	Primary outcome
Lymphoedema-specific QoL	Lymphoedema Functiong, Disability and Health (Lymph-ICF) questionnaire for upper or lower limb lymphoedema13 19 20 27	X			X
	Secondary outcomes
Self-reported questionnaire
Lymphoedema-specific QoL	See primary outcome	X	X	X		X	X
Duration (key secondary outcome) and experience of wearing compression garment	Compression questionnaire developed by the International Compression Club (or ICC compression questionnaire)28	X	X	X	X	X	X
Health-related QoL	EuroQol-5D-5L which is a health status measure developed by the EuroQol group containing 5 dimensions and 5 levels29	X	X	X	X	X	X
Work capacity and ability	Work Productivity and Activity Impairment questionnaire30; QuickScan 1831	X	X	X	X	X	X
Physical activity level	International Physical Activity Questionnaire32	X	X	X	X	X	X
Costs related to lymphoedema and its treatment*	Study-specific questionnaire		X	X	X	X	X
Usual care and self-management*†, including need for intensive treatment	Study-specific questionnaire		X	X	X	X	X
Assessments
Limb volume (key secondary outcome)	Circumference measurements every 4 cm with perimeter16 33–35	X	X	X	X	X	X
Hand/foot volume	Water displacement method of hand or foot34 36	X	X	X	X	X	X
Failure to reduce hours a day of wearing compression garment	Based on change in limb volume			X	X	X	X
Body weight	Scale	X	X	X	X	X	X
Infection previous 18 months	Interview	X			X		X
Recurrence of cancer	Interview and medical file				X		X
Adverse events and complications of surgery	Interview and medical file		X	X	X	X	X
Lymphatic transport	Lymphofluoroscopy using Indocyanine Green (or ICG fluoroscopy)37; lymphoscintigraphy38 39	X			X

*Information is collected on a monthly basis.

†No secondary outcome.

QoL, quality of life.