Table 1.
Baseline characteristics
| No switch (n = 479) |
One switch (n = 135) | Two switches (n = 35) |
Totala) (n = 655) |
||
|---|---|---|---|---|---|
| Female, n (%) | 427 (89.1%) | 122 (90.4%) | 31 (88.6%) | 586 (89.5%) | |
| Age, mean (SD) | 47.2 (11.4) | 46.6 (12.5) | 47.6 (13.2) | 47.1 (11.7) | |
| Time since migraine diagnosis in years, mean (SD) | 20.0 (13.6) | 20.1 (13.8) | 21.6 (13.0) | 20.0 (13.7) | |
| Chronic migraine, n (%) | 65 (13.6%) | 45 (33.3%) | 14 (40.0%) | 128 (19.5%) | |
| Number of prior preventive failures, n (%) | |||||
| 1 | 22 (4.6%) | 2 (1.5%) | 2 (5.7%) | 26 (4.0%) | |
| 2 | 102 (21.3%) | 48 (35.6%) | 17 (48.6%) | 170 (26.0%) | |
| 3 | 75 (15.7%) | 21 (15.6%) | 4 (11.4%) | 101 (15.4%) | |
| 4 | 83 (17.3%) | 21 (15.6%) | 2 (5.7%) | 107 (16.3%) | |
| 4+ | 129 (26.9%) | 28 (20.7%) | 5 (14.3%) | 163 (24.9%) | |
| Missing | 68 (14.2%) | 15 (11.1%) | 5 (14.3%) | 88 (13.4%) | |
| Previous Botox therapy, n (%) | 87 (18.2%) | 40 (29.6%) | 13 (37.1%) | 145 (22.1%) | |
| Education, n (%) | |||||
| Technical college | 39 (8.1%) | 13 (9.6%) | 4 (11.4%) | 57 (8.7%) | |
| High school diploma | 136 (28.4%) | 43 (31.9%) | 12 (34.3%) | 193 (29.5%) | |
| Secondary general school | 42 (8.8%) | 13 (9.6%) | 4 (11.4%) | 59 (9.0%) | |
| No qualifications | 1 (0.2%) | 1 (0.7%) | 0 (0.0%) | 2 (0.3%) | |
| Polytechnic high school | 14 (2.9%) | 0 (0.0%) | 0 (0.0%) | 14 (2.1%) | |
| Intermediate secondary school | 154 (32.2%) | 48 (35.6%) | 9 (25.7%) | 214 (32.7%) | |
| Elementary school | 4 (0.8%) | 2 (1.5%) | 3 (8.6%) | 9 (1.4%) | |
| Missing | 89 (18.6%) | 15 (11.1%) | 3 (8.6%) | 107 (16.3%) | |
| Employment, n (%) | |||||
| Education | 8 (1.7%) | 4 (3.0%) | 1 (2.9%) | 14 (2.1%) | |
| Employed (full time) | 156 (32.6%) | 46 (34.1%) | 12 (34.3%) | 215 (32.8%) | |
| Employed (part time) | 117 (24.4%) | 34 (25.2%) | 7 (20.0%) | 161 (24.6%) | |
| Retired | 40 (8.4%) | 24 (17.8%) | 10 (28.6%) | 75 (11.5%) | |
| Homemaker | 22 (4.6%) | 6 (4.4%) | 2 (5.7%) | 30 (4.6%) | |
| Unemployed | 14 (2.9%) | 5 (3.7%) | 1 (2.9%) | 20 (3.1%) | |
| Missing | 122 (25.5%) | 16 (11.9%) | 2 (5.7%) | 140 (21.4%) | |
| Comorbid psychiatric disorders, n (%) | |||||
| Somatoform disorders | 55 (11.5%) | 33 (24.4%) | 15 (42.9%) | 103 (15.7%) | |
| Depression | 116 (24.2%) | 52 (38.5%) | 7 (20.0%) | 175 (26.7%) | |
| Anxiety disorder | 22 (4.6%) | 12 (8.9%) | 3 (8.6%) | 39 (6.0%) | |
| Medication overuse, n (%) | 106 (22.1%) | 41 (30.4%) | 9 (25.7%) | 158 (24.1%) | |
| MHD, mean (SD) | 11.1 (5.5) | 13.3 (6.3) | 16.0 (7.4) | 11.6 (6.1) | |
| MMD, mean (SD) | 9.9 (4.5) | 12.3 (5.8) | 14.5 (6.6) | 10.7 (5.1) | |
| MDAM, mean (SD) | 8.1 (4.2) | 9.2 (4.4) | 8.7 (5.1) | 8.7 (4.7) | |
| HIT-6, mean (SD) | 65.3 (4.1) | 65.1 (4.9) | 65.3 (3.6) | 65.2 (4.3) | |
| MIDAS, mean (SD) | 62.7 (48.9) | 67.6 (46.3) | 57.3 (33.9) | 62.4 (46.8) | |
Baseline characteristics of the whole cohort and subgroups with no switch, one switch, and two switches. SD: standard deviation, MHD: monthly headache days, MMD: monthly migraine days, MDAM: monthly days of acute medication. a) Total cohort includes the group with 3 or more switches (n = 6), which is not displayed separately in this table due to the small sample size