Fig. 3.

Gene comethylation modules associated with development of the human pancreas. Across DNA methylation sites located in promoter regions, the module eigengene of the (A) Promoter4 module was most positively correlated with developmental age and the module eigengene of the (B) Promoter3 module had the strongest negative correlation with developmental age. Shown for each module is the module eigengene for each sample (left panel) and a heatmap depicting the mean DNA methylation for core sites in each module across development (right panel) with colour corresponding to DNA methylation level at sites with a module membership > 0.85. Across DNA methylation sites located in gene body regions, the module eigengene of the (C) GeneBody3 module was was most positively correlated with developmental age and the module eigengene of the (D) GeneBody4 module had the strongest negative correlation with developmental age