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. 2024 Jun 3;25:553. doi: 10.1186/s12864-024-10450-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The dramatic temporal changes in DNA methylation at fetal dDMPs is limited to the prenatal period. A Correlation of DNA methylation changes during fetal development (X-axis) and postnatal aging (Y-axis) at 176,624 dDMPs tested in both fetal and adult pancreas. No pancreas dDMPs were significantly associated with age in the postnatal pancreas. B DNA methylation at pancreas dDMPs was dramatically more variable in fetal pancreas samples than postnatal pancreas samples. Shown is the distribution of variance in DNA methylation across the 10,000 most significantly dDMPs in fetal pancreas samples (pink) (variance = 0.0150) compared to the variance in DNA methylation at the same sites in adult pancreas samples (blue) (0.0013). C DNA methylation at pancreas dDMPs was dramatically different between early fetal (6—8 PCW) and adult pancreas samples at the 10,000 most significant dDMPs. D In contrast, DNA methylation at pancreas dDMPs was highly correlated between early fetal (6—8 PCW) and adult pancreas samples at the same dDMPs (corr = 0.70)