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. 2024 Jun 3;25:553. doi: 10.1186/s12864-024-10450-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Overlap between developmental changes in DNA methylation between pancreas and brain. A Correlation of effect sizes at pancreas dDMPs with those at the same sites in the developing brain. B A site at which developmental changes in DNA methylation is highly similar between pancreas and brain. Shown is cg08486065 which is characterized by significant decrease in DNA methylation across development in both pancreas (effect size = 0.0362, P = 1.06 × 10^–54) and brain (effect size = 0.0341, P = 1.38 10^–12). C A site at which DNA methylation changes significantly across development in the pancreas and brain but in the opposite direction. Shown is cg16094352 which is characterized by significant hypermethylation across development in the pancreas (effect size = 0.0151, P = 3.13 × 10^–41) but significant hypomethylation across development in the brain (effect size = -0.00484, P = 1.68 × 10^–8). D A site at which developmental changes in DNA methylation are specific to the pancreas. Shown is cg08219218 annotated to LBRA that is characterized by significant hypermethylation across development in the pancreas (effect size = 0.0490, P = 4.52 × 10^–41) but no change in the brain. E Correlation of effect sizes at brain dDMPs with those at the same sites in the developing pancreas. F A site at which developmental changes in DNA methylation are specific to the brain. Shown is cg02192555 annotated to MSRA that is characterized by significant hypomethylation across development in the brain (effect size = -0.0371, P = 3.86 × 10^–12) but no change in the pancreas