FIG. 3.

Block of HSV-1(U21) entry by MAbs to nectin2. (A) Nectin2α-expressing cells were preincubated with MAb R2.525, BC12, or R2.477 to nectin2 or mouse IgGs (0.16 mg/ml) and then infected with HSV-1(U21). Infection was monitored by immunostaining 16 h later. (B) Nectin2α-expressing cells carrying α27p-LacZ were preincubated with the indicated concentrations of R2.525, BC12, and R2.477 antibodies or mouse IgGs and then infected with HSV-1(U21). Infection was quantitated as β-gal activity. A value of 100% represents the value obtained with infected cells not exposed to antibodies.