Table 3. Performance of the diagnostic performance of anti-BIRC5 autoantibody and AFP in evaluation phase.

	AUC (95% CI)	P	Cut off	Se (%) (95% CI)	Sp (%)(95% CI)	PPV (%)	NPV (%)	Accuracy (%)
Anti-BIRC5 autoantibody	0.726 [0.682–0.770]	<0.0001	0.351	30.7 [25.3–36.8]	89.8 [85.3–93.0]	75.0	56.4	60.3
AFP	0.844 [0.803–0.885]	<0.0001	20	61.1 [24.8–67.0]	99.6 [97.7–100.0]	99.3	71.9	80.3
Anti-BIRC5 autoantibody & AFP	0.914 [0.888–0.940]	<0.0001	0.5	77.5 [71.8–82.3]	91.8 [87.7–94.6]	90.4	80.3	84.6

Note:

Cut off: 0.351 was determined by the 90% percentile of Nanchang NCs, Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value.