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. 2024 May 30;16(1):2359729. doi: 10.1080/19490976.2024.2359729

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — D-glucaric acid suppressed myelin-related gene expression in neonatal mice.

(a) D-glucaric acid impact on neonatal hippocampal myelin-related gene was investigated, and the schematic diagram was illustrated. Created with BioRender.com.

(b) Body weight of P1–P10 100 mg/kg glucaric acid-treated mice. P1 (Control n = 18, D-Glucaric acid n = 19, t₃₅₀ = 0.02, p > 0.99, Sidak’s tests), P2 (Control n = 18, D-Glucaric acid n = 19, t₃₅₀ = 0.39, p > 0.99, Sidak’s tests), P3 (Control n = 18, D-Glucaric acid n = 19, t₃₅₀ = 0.58, p > 0.99, Sidak’s tests), P4 (Control n = 18, D-Glucaric acid n = 19, t₃₅₀ = 0.02, p > 0.99, Sidak’s tests), P5 (Control n = 18, D-Glucaric acid n = 19, t₃₅₀ = 0.32, p > 0.99, Sidak’s tests), P6 (Control n = 18, D-Glucaric acid n = 19, t₃₅₀ = 0.91, p = 0.99, Sidak’s tests), P7 (Control n = 18, D-Glucaric acid n = 19, t₃₅₀ = 0.26, p > 0.99, Sidak’s tests), P8 (Control n = 18, D-Glucaric acid n = 19, t₃₅₀ = 0.96, p = 0.98, Sidak’s tests), P9 (Control n = 18, D-Glucaric acid n = 19, t₃₅₀ = 0.28, p > 0.99, Sidak’s tests), P10 (Control n = 18, D-Glucaric acid n = 19, t₃₅₀ = 0.35, p > 0.99, Sidak’s tests).

(c) Quantitative real-time polymerase chain reaction (qRT-PCR) of Mbp and Plp1 using hippocampus from P10 mice. Mbp (n = 5 each, t₈ = 4.03, p < 0.05, Student’s t-test), Plp1 (n = 5 each, t₈ = 5.16, p < 0.05, Student’s t-test).

(d) D-glucaric acid impact on adult hippocampal myelin-related gene was investigated, and the schematic diagram was illustrated. Created with BioRender.com.

(e) Body weight of D1–D47 in glucaric acid-treated mice. D0 (Control n = 10, D-Glucaric acid n = 11, t₁₉ = 0.65, p > 0.99, Sidak’s tests), D4 (Control n = 10, D-Glucaric acid n = 11, t₁₉ = 0.02, p > 0.99, Sidak’s tests), D7 (Control n = 10, D-Glucaric acid n = 11, t₁₉ = 0.27, p > 0.99, Sidak’s tests), D12 (Control n = 10, D-Glucaric acid n = 11, t₁₉ = 0.26, p > 0.99, Sidak’s tests), D17 (Control n = 10, D-Glucaric acid n = 11, t₁₉ = 0.13, p > 0.99, Sidak’s tests), D21 (Control n = 10, D-Glucaric acid n = 11, t₁₉ = 0.79, p = 0.99, Sidak’s tests), D26 (Control n = 10, D-Glucaric acid n = 11, t₁₉ = 0.97, p = 0.99, Sidak’s tests), D33 (Control n = 10, D-Glucaric acid n = 11, t₁₉ = 1.94, p = 0.54, Sidak’s tests), D38 (Control n = 10, D-Glucaric acid n = 11, t₁₉ = 1.21, p = 0.95, Sidak’s tests), D44 (Control n = 10, D-Glucaric acid n = 11, t₁₉ = 0.75, p > 0.99, Sidak’s tests), D47 (Control n = 10, D-Glucaric acid n = 11, t₁₉ = 0.64, p > 0.99, Sidak’s tests).

(f) qRT-PCR of Mbp and Plp1 using hippocampus from treated adult mice. Mbp (Control n = 6, D-Glucaric acid n = 7, t₁₁ = 0.29, p = 0.29, Student’s t-test), Plp1 (Control n = 6, D-Glucaric acid n = 7, t₁₁ = 0.85, p = 0.41, Student’s t-test).

Mean ± SEM; ^★ indicates p < 0.05; P, postnatal day; D, day.