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. 2024 May 30;16(1):2359729. doi: 10.1080/19490976.2024.2359729

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 6. — D-glucaric acid treatment induces gene expression change in OPC differentiation-conditioned cells.

(a) Representative OPC to myelinating OL marker. Pdgfra is a progenitor marker. Enpp6 is the pre- and immature OL marker. Bcas1 represents pre- and immature OL to myelinating OL marker. Mbp and Plp1 are myelinating OL markers.

(b) Quantitative real-time polymerase chain reaction (qRT-PCR) of Pdgfra, Enpp6, Bcas1, Mbp, and Plp1 from OPC differentiation-conditioned cells. Pdgfra (n = 6 each, Control versus Glucaric acid 10 μM: q₁₅ = 1.99, p = 0.11, Control versus Glucaric acid 100 μM: q₁₅ = 0.86, p = 0.61, Dunnett’s test), Enpp6 (n = 6 each, Control versus Glucaric acid 10 μM: q₁₅ = 1.57, p = 0.23, Control versus Glucaric acid 100 μM: q₁₅ = 0.20, p = 0.11, Dunnett’s test), Bcas1 (n = 6 each, Control versus Glucaric acid 10 μM: q₁₅ = 3.50, p < 0.05, Control versus Glucaric acid 100 μM: q₁₅ = 4.04, p < 0.05, Dunnett’s test), Mbp (n = 6 each, Control versus Glucaric acid 10 μM: q₁₅ = 3.92, p < 0.05, Control versus Glucaric acid 100 μM: q₁₅ = 2.87, p < 0.05, Dunnett’s test), Plp1 (n = 6 each, Control versus Glucaric acid 10 μM: q₁₅ = 3.21, p < 0.05, Control versus Glucaric acid 100 μM: q₁₅ = 3.30, p < 0.05, Dunnett’s test).

Mean ± SEM; ^★ indicates p < 0.05; OPC, oligodendrocyte precursor cells; OL, oligodendrocytes.