TABLE 1.

The 24 most frequent drugs causing liver injury in the DILIN prospective study ranked highest to lowest frequency

#	Agent	Year of approval	Drug class	LiverTox likelihood category
1	Amoxicillin/Clavulanate	1984	Anti-infective	A
2	Trimethoprim/Sulfamethoxazole	1981	Anti-infective	A
3	Nitrofurantoin	1953	Anti-infective	A
4	Isoniazid	1953	Anti-infective	A
5	Minocycline	1971	Anti-infective	A
6	Atorvastatin	1996	Cholesterol lowering	A
7	Cefazolin	1973	Anti-infective	A
8	Azithromycin	1991	Anti-infective	A
9	Diclofenac	1988	Nonsteroidal anti-inflammatory	A
10	Ciprofloxacin	1987	anti-infective	A
11	Infliximab	1998	Immune modulator	A
12	Terbinafine	1996	Anti-infective	B
13	Amoxicillin	1974	Anti-infective	B
14	Azathioprine	1968	Immune modulator	A
15	Lamotrigine	1994	Antiepileptic	A
16	Levofloxacin	1996	Anti-infective	A
17	Phenytoin	1939	Antiepileptic	A
18	Mercaptopurine	1953	Immune modulator	A
19	Ipilimumab	2011	Immune modulator	A
20	Allopurinol	1966	Xanthine oxidase inhibitor	A
21	Carbamazepine	1968	Antiepileptic	A
22	Hydralazine	1953	Anti-hypertensive	A
23	Interferon beta	1993	Immune modulator	A
24	Methyldopa	1962	Anti-hypertensive	A

Note: The major class of drugs causing DILI are anti-infective agents. The most common causes are drugs that have been available for several decades.

Data from the US Drug-Induced Liver Injury Network (September 2021) with permission. LiverTox likelihood scores are updated periodically based on current DILI risk data.