Protein interaction networks enriched in the central body, optic lobe, and glia in Tau P251L knock-in brains compared with controls. Protein interaction networks are largely distinct among central body neurons, optic lobe neurons, and glia. Subnetworks including nodes enriched for protein catabolism (central body), electron transport chain (optic lobe), or fatty acid metabolism (glia) are highlighted. Interaction strength displayed in gray shows the stringency of the interaction: The lower the strength, the stronger the interaction.