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Synthesis of PSMA-targeted dendrimer-drug conjugate. (A) Synthesis of PSMA-targeting moiety terminating in amine reactive HNS ester; (B) Modification of DM1 with linker containing cleavable disulfide bond and NHS ester for conjugation with dendrimer; (C) Formulation of PSMA-targeted PT-DDC by consecutive conjugation of DM1 with cleavable linker (dashed arrow), NOTA, sulfo-Cy5, SA-KEU and capping the remaining primary amine with butane-1,2-diol groups.
