TABLE 1.
Sensitivity of CD46 transgenic mice to MV infection of the brain
| Mice | CD46 isoform | TCID50 inoculateda | Dead/ inoculated | Mean survival timeb |
|---|---|---|---|---|
| Transgenic linesc | ||||
| MCP-8 | C-Cyt1 | 3 × 105 | 9/9 | 6.0 ± 2.0 |
| 6 × 101 | 3/4 | 9.0 ± 1.0 | ||
| MCP-10 | C-Cyt1 | 3 × 105 | 9/9 | 6.2 ± 1.2 |
| 6 × 102 | 4/4 | 8.0 ± 3.4 | ||
| 6 × 101 | 5/7 | 8.4 ± 2.2 | ||
| 6 × 100 | 1/6 | 8.0 | ||
| MCP-3 | C-Cyt2 | 3 × 105 | 7/7 | 7.0 ± 1.2 |
| 3 × 104 | 8/8 | 6.4 ± 1.1 | ||
| 3 × 103 | 6/7 | 7.5 ± 0.8 | ||
| 3 × 102 | 1/4 | 10.0 | ||
| MCP-7 | C-Cyt2 | 3 × 105 | 17/17 | 5.7 ± 0.9 |
| 3 × 104 | 16/16 | 6.0 ± 0.8 | ||
| 6 × 103 | 12/12 | 6.3 ± 1.4 | ||
| 6 × 102 | 9/9 | 8.7 ± 0.7 | ||
| 6 × 101 | 1/6 | 13 | ||
| Nontransgenic littermates | 3 × 105 | 0/42 | ||
| BALB/c | 3 × 105 | 1/12 | 22 | |
| 3 × 104 | 0/5 |
a
Suckling mice were inoculated intracerebrally with the indicated dose of MV (Edmonston strain) and observed daily for 2 months thereafter.
b
Average day of death ± SD after MV inoculation, calculated from mice not surviving MV infection.
c
Transgenic mice were used as homozygotes for the MCP-3 and MCP-7 lines and as heterozygotes for the MCP-8 and MCP-10 lines.