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. Author manuscript; available in PMC: 2024 Jun 3.
Published in final edited form as: Cell Stem Cell. 2024 Apr 19;31(5):657–675.e8. doi: 10.1016/j.stem.2024.03.017

Figure 1. Transcriptomic profiling at single-cell resolution of primary adult human AT1s.

Figure 1.

(A) UMAP of an integrated analysis of 15,769 primary distal lung epithelial cells (from Basil et al., N = 5, including 1,401 AT1s and 7,039 AT2s).37

(B) Expression of indicated AT2 marker genes; lung epithelial marker NKX2–1; canonical AT1 marker genes; mouse-specific AT1 marker genes; and more recent human AT1 marker genes.

(C) Heatmap showing average expression for each cell type of top differentially upregulated human AT1 genes compared with all distal lung cells.

(D and E) (D) Expression of selected AT1 and AT2 marker genes and (E) Hippo signaling-related genes across all lung cell types.

(F) AGER expression across indicated cell types. See also Figure S1 and Table S1.