Table 3.

Clinical evidence regarding treatment with methotrexate in AOSD

Author	Drug	Design	No. of patients	Reference
Fautrel et al.	MTX	Retrospective, uncontrolled	26	[37]
Kalyonku et al.	MTX	Prospective multicentre	202	[38]
Pay et al.	MTX	Retrospective multicentre	61	[39]
Iliou et al.	MTX	Retrospective, uncontrolled	11	[40]
Franchini et al.	MTX	Retrospective monocentre	27 (five combination of DMARDs)	[41]
Fuji et al.	MTX	Retrospective monocentre	13	[42]
Singh et al.	MTX	Retrospective	10	[43]
Nordström et al.	MTX	RCT	6	[44]
Woo et al.	MTX	RCT	45	[45]
Aydintug et al.	MTX	Case series	6	[46]
Manger et al.	MTX	Review	71	[47]
Wang et al.	MTX	Prospective	28	[54]

AOSD: adult-onset Still’s disease.