Fig. 1. 10E8-class bnAb precursors are present in most humans.

a, Schematic of the epitope scaffold design showing antibody 10E8 (gray) and Env (blue), including the MPER (purple) that was grafted onto an unrelated epitope scaffold (cyan). b, Frequency of 10E8-class IgH precursors in 14 NGS datasets^7,27 of heavy chains from HIV-seronegative humans defined as sequences with genes encoding V_H closely related to 10E8 and HCDR3 lengths of 21–24 aa with a YxFW motif at the correct position. Lines indicate the median and 25 and 75% quantiles; HCs, heavy chains.