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. 2024 May 30;25(6):1073–1082. doi: 10.1038/s41590-024-01833-w

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© The Author(s) 2024, corrected publication 2024

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Fig. 2 — a, SPR-measured monovalent K_d values for the scaffold without germline-targeting mutations (MPER) and various 10E8-GT scaffolds (10E8-GT9.2 to 10E8-GT12) binding to mature 10E8, germline-reverted 10E8 (10E8-iGL3), the proposed 10E8 UCA¹⁸ and multiple NGS-derived 10E8-class human precursor heavy chains paired with the germline-reverted 10E8 light chain (NGS). Each symbol represents a different antibody; LOD, limit of detection; NB, no binding. b, SPR-measured monovalent K_d values for 10E8-GT10.2, 10E8-GT11 and 10E8-GT12 binding to different antibodies containing the indicated number of 10E8-class mutations, including fully germline-reverted 10E8 (10E8-iGL3), partially mature 10E8-class antibodies (intermediates) and mature (Mat) 10E8.