TABLE 1.
Measurements of TA muscle weighth and forcesa
| Hamster | Muscle weight in mg (n) | Specific twitch force in N/cm2 (n) | Specific tetanic force in N/cm2 (n) |
|---|---|---|---|
| F1B (wild type) | 117 ± 9 (8) | 9.3 ± 1.5 (8) | 22.8 ± 2.3 (8) |
| Bio14.6 (untreated) | 172 ± 13 (9) | 5.5 ± 1.2 (9) | 15.6 ± 2.8 (9) |
| Bio14.6 (AAV vector treated) | 111 ± 7 (4) | 9.2 ± 0.8 (4) | 22.6 ± 1.7 (4) |
a
Forty-day-old male Bio14.6 hamsters were injected with 1011 particles of an δ-SG–AAV vector into the TA muscle. At 4 months after vector injection, the animals were sacrificed and the TA muscle was isolated. Age-matched F1B hamsters (wild type) and Bio14.6 hamsters (mutant) not treated with the recombinant AAV vector were used as controls. The in vitro muscle force measurement was performed according to standard protocols (see Materials and Methods). The weight of the TA muscle was determined on an analytic balance after force measurement. All values in the table include standard deviations.