FIG. 1.

Physiological effect of H5 influenza virus infection of BALB/c mice. (A) Body temperatures of BALB/c mice after inoculation with HP avian influenza viruses. Body temperatures of individual mice were read on days 1 to 4, 6, 8, and 12 p.i. with a scanner. Values represent the means ± standard errors of the mean of eight mice per group. (B) Percent change in initial body weights of BALB/c mice after inoculation with HP avian influenza viruses. Body weights were taken on days 0, 4, 6, 8, and 12 p.i. The percent change in body weight was calculated for each mouse based on the initial starting weight at day 0 before virus inoculation. Each value represents the average percent change in weight ± standard error of the mean for eight mice per group. (a), All HK156 and HK220 mice died by day 8 p.i.; (b), two of eight HK728 mice died by day 8 p.i.; (c), four of six HK728 mice died by day 10 p.i.; ∗, significant at a P value of <0.05; ∗∗, significant at a P value of <0.001.