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. 2024 Jun 3;15:4700. doi: 10.1038/s41467-024-49067-6

Fig. 6. FADS2 expression levels correlate with apoptosis sensitization upon co-treatment of BH3-mimetics with unsaturated fatty acids.

Fig. 6

A WB analysis FADS2 expression levels in lung cancer cells (PC9, A549, H460, H358, and H1975), human kidney cells (HK2), and kidney cancer cells (786-O and OC-RC2). B Cell death kinetics, measured by % DRAQ7 positive cells, in lung cancer cell lines. Cells were fed with the indicated amounts of unsaturated lipids (linoleic acid or vehicle) for 18 h, then treated or not with ABT-737 (10 µM) and S63845 (10 µM) for apoptosis induction. Data are presented as means ± S.D..; n = 3 independent experiments. C Cell death kinetics, measured by % DRAQ7 positive cells, in kidney cancer cell lines. Cells were fed with the indicated amounts of unsaturated lipids (linoleic acid or vehicle) for 18 h, then treated or not with ABT-737 (10 µM) and S63845 (10 µM) for apoptosis induction. Data are presented as means ± S.D.; n = 3 independent experiments. Source data are provided as a Source Data file.