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. 2024 Apr 10;43(11):2166–2197. doi: 10.1038/s44318-024-00093-6

Figure 9. Model for role of DNAJC9 in preventing CENP-A mislocalization and chromosomal instability by maintaining the fidelity of H3–H4 supply chains.

Figure 9

In the context of wild-type DNAJC9 with unperturbed H3–H4 supply, CENP-A localizes to the centromeric region, maintaining normal chromosome segregation status. We propose that loss of DNAJC9 function reduces the supply of H3–H4 (Hammond et al, 2021) and promotes the mislocalization of CENP-A to noncentromeric regions in an MCM2-mediated pathway. Ectopic localization of CENP-A leads to higher incidence of CIN phenotypes. Illustrations created with BioRender.com.