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. 2024 May 31;56(5):1221–1229. doi: 10.1038/s12276-024-01197-z

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© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Percentage of initial weight (a), survival rate (b), and clinical disease symptoms (c) of the double-Tg mice infected with 1 × 10¹–10⁵ PFU SARS-CoV-2. Clinical disease symptoms were scored as described in the “Materials and methods”. Infectious viral titers in the lungs (d) and viral burdens in the lungs (e) and nasal turbinate (f) of the double-Tg mice infected with 2 × 10³ PFU SARS-CoV-2 (6 days post-infection; dpi) were detected by using a plaque assay and RT-qPCR, respectively. g Representative images of SARS-CoV-2 nucleocapsid protein (NP) immunostaining in the lungs of C57BL/6 (non-Tg) and double-Tg mice. Images show low (left; bars, 100 μm) and high magnification (right; bars, 100 μm). Symbols represent means ± SEM. Statistically significant differences between the groups were determined using multiple two-tailed t-tests (a, c).