Table 2.
Intraoperative variables in patients received remimazolam-flumazenil or propofol during radiofrequency catheter ablation of atrial fibrillation.
| Remimazolam-flumazenil group (n = 26) |
Propofol group (n = 27) |
P | |
|---|---|---|---|
| Time to loss of consciousness (s) | 101 (84–114) | 121 (70–161) | 0.328 |
| Time to eye opening (s) | 174 (157–216) | 353 (230–483) | < 0.001 |
| Time to extubation (s) | 211 (177–268) | 382 (308–572) | < 0.001 |
| Duration of procedure (min) | 142 (39) | 135 (42) | 0.532 |
| Total infused remifentanil (μg) | 656 (271) | 623 (170) | 0.604 |
| Total administered propofol (mg) | 1195 (268) | NA | |
| Total administered remimazolam (mg) | 354 (108) | NA | |
| Total administered flumazenil (mg) | 0.3 (0.3–0.4) | NA | |
| Total infused crystalloid (mL) | 600 (475–763) | 600 (350–700) | 0.447 |
| Urine output (mL) | 400 (233–915) | 650 (300–855) | 0.552 |
| Incidence of intraprocedural hypotension* | 3 (12%) | 1 (4%) | 0.341 |
| Use of norepinephrine during procedure | 22 (85%) | 24 (89%) | 0.704 |
| Maximum dosage of norepinephrine administration (μg/kg/min) | 0.04 (0.02–0.06) | 0.04 (0.02–0.07) | 0.641 |
| Duration of norepinephrine infusion (min) | 94 (66) | 107 (64) | 0.458 |
Data are presented as median (interquartile range), mean (SD), or number (%). NA, not applicable.
*Intraoperative hypotension was defined when three consecutive systolic blood pressure < 80 mmHg at 2.5 min-interval was detected.