Table 2.

Diagnostic accuracy (area under the curve, AUC) of hsCRP and lipidomic signatures in predicting pediatric inflammatory bowel disease compared to symptomatic controls in the validation cohort

Evaluated models	AUC (95% CI)	P value vs hsCRP
hsCRP	0.73 (0.63–0.82)	reference
Full model (30 molecular lipid species)	0.85 (0.77–0.92)	0.001
LacCer(d18:1/16:0)	0.76 (0.67–0.84)	0.53
hsCRP + LacCer(d18:1/16:0)	0.79 (0.70–0.87)	0.09
PC(18:0p/22:6)	0.71 (0.61–0.81)	0.80
hsCRP + PC(18:0p/22:6)	0.76 (0.66–0.85)	<0.001
PC(18:0p/22:6) + LacCer(d18:1/16:0)	0.86 (0.78–0.92)	<0.001
hsCRP + LacCer(d18:1/16:0) + PC(18:0p/22:6)	0.86 (0.77–0.92)	<0.001

AUC area under the curve, CI confidence interval, hsCRP high sensitivity C-reactive protein.