Figure 2.
Survival of BALB/c mice immunized with Δcaf1 or ΔyopD/Δcaf1 regimens and challenged with aerosolized Y. pestis C12. (A) Female (F) and male (M) mice (n = 10/group) were vaccinated with the Δcaf1 regimens in the legend, with 21 days between injections, then challenged with C12 (4.7 x 105 CFU for females, 5.7 x 105 CFU for males) at 28 d post-boost. (B) Female (F) and male (M) mice (n = 10/group) were vaccinated with the ΔyopD/Δcaf1 regimens in the legend, with 21 days between injections, then challenged with C12 (2.0 x 105 CFU for females, 2.4 x 105 CFU for males) at 29 d post-boost. Clinical progression was monitored daily for 21 days. *p < 0.05, **p < 0.01 in pairwise comparison of groups by probability of survival (%) using a Fisher exact test.