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. 2024 May 21;15:1386243. doi: 10.3389/fimmu.2024.1386243

Figure 2.

Figure 2

Spike-specific T cell responses in the lungs of C57BL/6 mice. (A) representative flow cytometry plots showing spike-specific T cell responses for each animal group. (B) spike-specific CD4+ T cell responses. (C) spike-specific lung CD8+ TRM. (D, E) total, and spike-specific lung CD4+ TRM, respectively. (F, G) total, and spike-specific lung CD8+ TRM, respectively. Empty circle dots: female; Solid circle dots: male in (B–G). Data are representative of two independent experiments (n=4 or 5 per sex). Non-parametric one-way ANOVA using the Kruskal-Wallis test followed by corrected Dunn’s multiple comparisons tests was conducted in Prism to analyze cellular responses across groups 1–5. The significance levels for p-values were denoted as follows: 0.1234 (ns), 0.0332 (*), 0.0021(**), 0.0002 (***), <0.0001 (****) (B–G).