FIG. 6.

Schema of the potential interactions of RBP-Jκ and endogenous and exogenous forms of activated NOTCH1. In BJAB cells, RBP-Jκ is available for interaction with the transfected forms of NOTCH1, therefore activating the promoters. In Jurkat cells, the available RBP-Jκ is sequestered with endogenous activated forms of NOTCH1 and competes with the transfected NOTCH1 molecules, resulting in a dominant negative phenotype that is seen by repression of the EBV latent promoters.