TABLE 1.
Viremia in woodchucks infected with WHVa
| No. of weeks p.i. | Virus titer (108 virions/ml)
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cohort I
|
Cohort II
|
|||||||||
| 22 | 35 | 36 | 38 | 400 | 401 | 402 | 403 | 405 | 406 | |
| 0 | — (B) | — (B) | — (B) | — (B) | — (B) | — (B) | — (B) | — (B) | — (B) | — (B) |
| 1 | 2 | 1.4 | — | — | — | 2.1 | 5 | — | 1.8 | — |
| 2 | 13 (B) | 24 | 2 | 0.3 | 1.7 | 20 | 115 | 4 | 17 | — |
| 3 | 28 | 38 (B) | 27 (B) | 5.2 (B) | 30 | 1.7 | — | 76 | 850 | — |
| 4 | 37 | 16 | 14 | — (B) | — (B) | — (B) | 4.5 (B) | 40 (B) | — (B) | |
| 5 | 29 | 29 | 12 | 4.5 | — | — | — | — | 5 | — |
| 6 | 33 (B) | 10 | 13 | 4.0 | — | — | — | — | — | — |
| 7 | 9 | 3 (B) | 6 (B) | 4.8 (B) | B | B | B | |||
| 8 | 9 | 0.6 | 2 | 5.9 | B | B | ||||
| 9 | 2 | 0.1 | — | 5.6 | ||||||
| 10 | B | — | — | 3.9 | B | B | B | B | B | B |
| 11 | — | — (B) | — (B) | 4.2 (B) | B | B | ||||
| 12 | — | |||||||||
| 13 | 1.5 | |||||||||
| 14 | — | |||||||||
| 15 | 0.7 | |||||||||
| 16 | 0.03 | |||||||||
| 17 | B | — (B) | ||||||||
| 18 | — | |||||||||
| 19 | B | |||||||||
| 21 | — (B) | |||||||||
| 22 | B | B | ||||||||
| 29 | B | |||||||||
a
Virus titers of cohort I animals were determined by Southern blot analysis of virion DNA extracted from virus particles that were pelleted from serum samples by ultracentrifugation (14). Virus titers of cohort II animals were determined by dot blot hybridization analysis of 5 μl of serum. —, below the level of detection; B, liver biopsy was performed at time point indicated.