Figure 2.

Genetic loci for head size and effects on regional brain volumes

(A) Heatmap showing head size loci that overlap with previously identified loci for global brain volumes (red), subcortical volumes (blue), and cortical region of interest volumes (green).

(B) UpSet plot of associations between head size lead variants and brain volumes. Intersection size corresponds to the frequency of the combination depicted below the bar. Set size corresponds to the frequency of associations with one of the brain volume categories (i.e., global, subcortical, or cortical).

(C) Plot showing the subcortical shape analysis of rs111939932 using log Jacobian determinants. Colors correspond to t values, with positive associations depicted in blue, and negative ones in red. Letters point to different subcortical structures: a, putamen; b, pallidum; c, caudate; d, amygdala; e, hippocampus; f, thalamus; g, accumbens.