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Effects of PKR and IFN on viral production. IFN-treated or untreated 3T3 L1 cells (VEC) inducibly expressing wild-type PKR (WT) or dominant-negative variant PKR-Δ6 (Δ6) were infected with WSN (a), VSV (b), or SNV (c) at an MOI of 10; 24 (WSN) or 48 (VSV and SNV) h later, samples of medium from the infected cells were retrieved and viral production was determined by plaque assay. Data represent means of three experiments ± standard deviation.
