Figure 4.

2B7 and 2C1 antibodies reveal two distinct sites on gp42

(A) The semi-transparent cryo-EM maps of the EBV gH/gL/gp42-2B7 Fab complex. The model structure of EBV gH/gL/gp42/2B7 Fab is aligned with the low-pass-filtered electron density as a reference.

(B) Zoomed-in views of a semi-transparent map superimposed with the atomic models generated by crystal diffraction.

(C) The 2B7 epitope (yellow), 2C1 epitopes (blue), and HLA-DR1 binding site (red) are mapped on gp42 (gray).

(D) Structure model of gp42 (gray) in complex with HLA-DR1 (red), 2C1 Fab (blue), and 2B7 Fab (yellow).

See also Figure S6.