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. Author manuscript; available in PMC: 2024 Jun 4.
Published in final edited form as: Environ Sci Technol. 2021 Dec 8;55(24):16502–16514. doi: 10.1021/acs.est.1c04455

Table 2.

Adjusted Effect Contribution for Each Averaged Chemical Biomarker Concentration Included in the Overall Mixture Effect on Nonverbal IQ (n = 708)a

negative effect contribution weight positive effect contribution weight
biomarker B 95%CI % B 95%CI %
Phthalate Metabolites
MMP −0.29 −1.36, 0.78 5.3
MEP −0.21 −1.39, 0.98 3.8
MCPP −0.84 −2.07, 0.38 15.5
MiBP −0.77 −2.08, 0.55 14.1
MnBP 0.46 −0.88, 1.81 12.2
MECPP −1.44 −2.95, 0.07 26.5
MCMHP 0.68 −0.58, 1.93 17.9
MBzP 0.41 −0.68, 1.50 10.8
PA −0.41 −1.70, 0.88 7.6
MEOHP 0.94 −1.31, 3.18 24.6
MEHHP 0.38 −1.70, 2.46 10.0
total −3.96 72.8 2.87 75.5
Bisphenol - -
BPA 0.41 −0.61, 1.43 10.9
total 0.41 10.9
OP Pesticide Metabolites
DMDTP −0.08 −1.42, 1.27 1.4
DMTP −0.79 −2.35, 0.76 14.6
DMP −0.61 −1.92, 0.70 11.2
DETP 0.26 −1.01, 1.53 6.8
DEP 0.26 −1.05, 1.56 6.8
total −1.48 27.2 0.52 13.6
Total Mixture
total −5.44 100% 3.80 100%
a

Models adjusted for fetal sex, maternal age, maternal prepregnancy bmi, maternal education level, maternal ethnicity, household income, marital status, parity, maternal smoking, maternal alcohol use, maternal IQ, and child age at assessment. Abbreviations: MEP = monoethyl phthalate, MMP = monomethyl phthalate, MiBP = monoisobutyl phthalate, MnBP = mono-n-butyl phthalate, MECPP = mono-(2-ethyl-5-carboxypentyl) phthalate, MCMHP = mono-[(2-carboxymethyl) hexyl] phthalate, MEOHP = mono-(2-ethyl-5-oxohexyl) phthalate, MEHHP = mono-(2-ethyl-5-hydroxyhexyl) phthalate, MCPP = mono(3-carboxypropyl) phthalate, mBzP = monobenzyl phthalate, PA = phthalic acid, BPA= bisphenol A, DMDTP = dimethyldithiophosphate, DMTP = dimethylthiophosphate, DMP = dimethylphosphate, DETP = diethylthiophosphate, and DEP = diethylphosphate.