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GI50 concentrations of pentoxifylline in two pairs of sensitive and MDR counterpart NSCLC cell lines
| Drug | GI50* (mM) | |||
| NCI-H460 | NCI-H460/R | A549 | A549-CDR2 | |
| Pentoxifylline | 0.96 ± 0.08 | 1.17 ± 0.17 | 1.23 ± 0.07 | 1.53 ± 0.04 |
*GI50 concentration (which causes 50% inhibition of cell growth) after 48 h of drug treatment (determined with the SRB assay). MDR: Multidrug resistance; NSCLC: non-small cell lung cancer; SRB: sulforhodamine B.
