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. 2024 Jun 4;24:197. doi: 10.1186/s12935-024-03377-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — STX6 is upregulated in HCC patients and correlates to HCC progression. (A) Results of STX6 expression level analysis in human HCC tissues (n = 347) and normal tissues (n = 50) in TCGA databases. (B) STX6 expression levels in HCC samples of different histologic grades in TCGA databases. Histologic grading grade I, n = 60; grade II, n = 205; grade III, n = 139; grade IV, n = 12. (C) STX6 mRNA levels in HCC samples with different TNM stages in TCGA databases. Stage I, n = 191; Stage II, n = 98; Stage III, n = 97; Stage IV, n = 6. (D) Kaplan-Meier overall survival curves of HCC patients with high and low STX6 expression in the TCGA database. (E) STX6 mRNA levels in paired HCC and paracancerous tissues. β-actin was used to normalize. Data was given as mean ± SD. (F) The WB and quantification results of STX6 in HCC tissues and paracancerous tissues. GAPDH served as the loading control. Data was given as mean ± SD. (G) Results of IHC analysis of STX6 in HCC tissues and paracancerous tissues. Data was given as mean ± SD. For statistical analysis, two-tailed Student’s t-test was used in E-G. * P < 0.05; ** P < 0.01