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. 2024 Jun 4;24:197. doi: 10.1186/s12935-024-03377-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — STX6 promotes HCC tumorigenic behavior in vivo. (A) Representative images of HepG2 shRNA- and HepG2 shSTX6-derived xenograft tumors. n = 6 per group. (B) STX6 expression in HepG2 shRNA- and HepG2 shSTX6-derived xenograft tumors. (C) Results of tumor volume analysis at different days after HepG2 cells’ injection. n = 7 per group. (D) Tumor weight of HepG2 shRNA- and HepG2 shSTX6-derived xenograft tumors. n = 7 per group. (E-F) The representative images (E) and quantification results (F) of immunohistochemical staining of PCNA and Ki-67 in the HepG2 shRNA- and HepG2 shSTX6-derived xenograft tumors. n = 4 per group. (G-H) Protein levels (G) and quantification results (H) of PCNA, cyclin D1, E-cadherin and N-cadherin in HepG2 shRNA- and HepG2 shSTX6-derived xenograft tumors. n = 3 per group. β-actin served as the loading control. Data was given as mean ± SD. (I) Representative images of Huh7 shRNA- and Huh7 shSTX6-derived xenograft tumors. n = 6 per group. (J) Results of tumor volume analysis at different days after Huh7 cells’ injection. n = 7 per group. (K) Tumor weight of Huh7 shRNA- and Huh7 shSTX6-derived xenograft tumors. n = 7 per group. (L) The representative images and quantification results of immunohistochemical staining of PCNA and Ki-67 in the Huh7 shRNA- and Huh7 shSTX6-derived xenograft tumors. n = 4 per group. For statistical analysis, the two-tailed Student’s t-test was used in C, D, F, H and J-L. n.s. indicates no significant difference; * P < 0.05; ** P < 0.01