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. 2024 Jun 4;24:197. doi: 10.1186/s12935-024-03377-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — STAT3 phosphorylation mediated the promotive role of STX6 in HCC progression. (A) Protein levels and quantification results of total and phosphorylated STAT3 in control and Huh7 STX6-OE cells treated with p-STAT3 inhibitor or DMSO. β-actin served as the loading control. (B) The representative images and quantification results of control and Huh7 STX6-OE cells treated with p-STAT3 inhibitor or DMSO in colony formation assays. n = 3 per group. (C) The representative images and quantification results of control cells and Huh7 STX6-OE cells treated with p-STAT3 inhibitor or DMSO in Transwell migration assays. n = 6 per group. (D) Protein levels and quantification results of PCNA, cyclin D1, E-cadherin and N-cadherin in control and Huh7 STX6-OE cells treated with p-STAT3 inhibitor or DMSO. n = 6 per group. β-actin served as the loading control. Data was given as mean ± SD. For statistical analysis, the two-tailed Student’s t-test was used in A-D. n.s. indicates no significant difference; * P < 0.05; ** P < 0.01