Figure 2.

A chemoresistant subpopulation of OCCC is associated with HIF activation and a poor prognosis

(A) Kaplan-Meier plots of advanced-stage OCCC (stages II–IV, n = 30). The top 20 genes highly expressed by each cancer subpopulation (Cancer #1–6) were selected as signature genes and used to classify the 30 cases of advanced OCCC (stages II–IV) into groups with high or low expression of signature genes. Kaplan-Meier curves show progression-free survival and overall survival in each group. p values were calculated using log rank test.

(B) Dot plot presentation of Gene Ontology (GO) terms specifically enriched in cancer subpopulations (Cancer #1–5).

(C) Heatmap of normalized ssGSEA enrichment scores for Hallmark pathways in cancer subpopulations (Cancer #1–6).