. 2024 Jun;65(6):971–979. doi: 10.2967/jnumed.123.266686

TABLE 2.

VOI Kinetics Recovered Using Different Methodologies

Method	Region	V_b (mL/g)	V_d (mL/g)	K_d(mL/min/g)	K_i (mL/min/100 g)	MTT (min)	Ext (%)
Voxel-NP	GM	0.05 ± 0.01	0.88 ± 0.26	0.16 ± 0.03	3.01 ± 0.81	5.80 ± 1.64	18.38 ± 5.18
	WM	0.03 ± 0.01	0.64 ± 0.27	0.10 ± 0.03	1.09 ± 0.33	6.61 ± 2.04	12.30 ± 4.12
	Lung	0.18 ± 0.04	0.09 ± 0.03	0.03 ± 0.01	0.07 ± 0.04	3.17 ± 0.77	3.17 ± 1.82
	Liver	0.09 ± 0.04	0.86 ± 0.08	0.54 ± 0.11	0.23 ± 0.08	1.77 ± 0.41	0.57 ± 0.38
	Spleen	0.21 ± 0.09	0.42 ± 0.09	0.41 ± 0.14	0.23 ± 0.16	1.39 ± 0.54	1.14 ± 2.09
	Kidney	0.25 ± 0.07	1.20 ± 0.34	0.49 ± 0.11	0.42 ± 0.25	2.62 ± 0.60	1.22 ± 0.97
	Bladder	0.00 ± 0.01	0.54 ± 0.32	0.04 ± 0.03	1.46 ± 1.13	6.73 ± 2.85	19.11 ± 11.36
	Bones	0.03 ± 0.02	0.22 ± 0.07	0.08 ± 0.02	0.27 ± 0.08	3.54 ± 0.79	4.66 ± 1.32
	Tumor	0.08 ± 0.05	0.65 ± 0.38	0.19 ± 0.08	2.33 ± 1.59	3.62 ± 1.57	12.93 ± 6.44
VOI-NP	GM	0.04 ± 0.01^*	0.58 ± 0.16^*	0.13 ± 0.03^*	3.25 ± 0.89^*	4.53 ± 1.19^*	20.13 ± 5.42
	WM	0.02 ± 0.01^*	0.58 ± 0.31^†	0.09 ± 0.03	1.10 ± 0.38	5.99 ± 2.25^†	10.96 ± 4.37
	Lung	0.17 ± 0.04^†	0.08 ± 0.03^‡	0.03 ± 0.02	0.08 ± 0.04^†	2.43 ± 0.65^*	2.66 ± 1.48
	Liver	0.05 ± 0.04^*	0.83 ± 0.07^‡	0.53 ± 0.13	0.28 ± 0.08^*	1.64 ± 0.39^*	0.57 ± 0.24
	Spleen	0.18 ± 0.09^†	0.39 ± 0.11^‡	0.46 ± 0.17^‡	0.29 ± 0.19^*	0.91 ± 0.22^*	0.86 ± 1.38^‡
	Kidney	0.23 ± 0.08	1.19 ± 0.37	0.51 ± 0.15	0.30 ± 0.26^‡	2.46 ± 0.82	0.62 ± 0.51^*
	Bladder	0.00 ± 0.01^*	0.44 ± 0.29^†	0.03 ± 0.03^*	1.61 ± 1.21^†	13.85 ± 11.15^*	33.87 ± 26.48^*
	Bones	0.01 ± 0.01^*	0.17 ± 0.08^*	0.08 ± 0.03	0.29 ± 0.07^*	2.24 ± 0.50^*	3.80 ± 0.90^†
	Tumor	0.07 ± 0.04^*	0.45 ± 0.34^*	0.18 ± 0.09^‡	2.48 ± 1.62^*	2.62 ± 1.59^*	13.27 ± 7.68
VOI-2C	GM	0.03 ± 0.01^*	0.56 ± 0.23	0.09 ± 0.02^*	3.12 ± 0.87^†	5.91 ± 1.71^‡	26.41 ± 6.41^*
	WM	0.02 ± 0.01^*	0.55 ± 0.16	0.05 ± 0.01^*	1.13 ± 0.32	11.00 ± 3.23^*	18.65 ± 4.48^*
	Lung	0.15 ± 0.04^*	0.09 ± 0.03^‡	0.04 ± 0.01^†	0.07 ± 0.04^‡	1.18 ± 1.44^*	1.70 ± 0.83^*
	Liver	0.02 ± 0.01^*	0.88 ± 0.09^*	0.53 ± 0.13	0.23 ± 0.08^*	1.68 ± 0.33	0.45 ± 0.21^*
	Spleen	0.11 ± 0.05^*	0.49 ± 0.12^*	0.61 ± 0.18^*	0.21 ± 0.21^*	0.73 ± 0.32^*	0.69 ± 1.97^*
	Kidney	0.15 ± 0.05^*	1.25 ± 0.36^‡	0.42 ± 0.11^†	0.21 ± 0.22^‡	2.81 ± 1.18^‡	0.52 ± 0.54
	Bladder	0.00 ± 0.00	0.05 ± 0.10^*	0.01 ± 0.02^*	1.63 ± 0.95	1.66 ± 5.36^*	86.89 ± 29.33^*
	Bones	0.00 ± 0.00^*	0.20 ± 0.06^†	0.08 ± 0.03	0.26 ± 0.07^*	2.65 ± 0.65^*	3.53 ± 0.94^‡
	Tumor	0.05 ± 0.05^*	0.34 ± 0.19	0.17 ± 0.10	2.38 ± 1.50^‡	1.80 ± 1.26^†	16.83 ± 18.38

P < 0.001.

^†

P < 0.01.

^‡

P < 0.05.

MTT = mean transit time; Ext = extraction fraction; voxel-NP = VOI-averaged voxel kinetics; GM = gray matter; WM = white matter; VOI-NP = VOI time course kinetics obtained by NP; VOI-2C = VOI time-course kinetics obtained by 2C.

Values are mean ± SD.