Figure 1: Multivariable Cox proportional hazard analysis for overall survival.

Each point represents the hazard ratio (HR) with 95% confidence intervals (CI) for the corresponding value of the given covariate compared to its reference. Covariates in model A included hepatic (vs. extrahepatic only) metastases at baseline, ECOG ≥ 1 (vs. 0), elevated LDH or ALP, use of anti-CTLA-4, use of anti-PD-1, and female sex; B replaced anti-CTLA-4 and anti-PD-1 with a single treatment variable (ICI vs. other local/systemic treatment vs. no treatment). Of 71 patients, 50 experienced events (death) and 12 were excluded due to missing data.