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. 2024 Apr 29;82:ftae008. doi: 10.1093/femspd/ftae008

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© The Author(s) 2024. Published by Oxford University Press on behalf of FEMS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Platform for analysis of immune correlates of protection. Groups (n = 7–8) of C57BL/6 J mice were immunized intranasally with irrelevant antigen, BSA, or live chlamydial EB, or intramuscularly with live chlamydial EB on day 0. On day 60, mice were challenged i.vag with C. muridarum. (A) Mean ± SEM of vaginal chlamydial shedding at indicated time-periods is shown. Significant (P ≤ 0.05; ANOVA) difference between * live EB i.n. versus BSA i.n., ** live EB i.m. versus BSA i.n., *** i.n live EB versus i.m. live EB. On day 80 following challenge, oviduct pathology was evaluated. (B) Percentage of mice displaying hydrosalpinx is shown. Significant (P ≤ 0.05; Fisher's exact test) difference between * live EB i.n. versus BSA i.n., ** live EB i.m. versus BSA i.n., *** i.n live EB versus i.m. live EB. (C) the incidence of dilated oviducts and mean ± SEM of oviduct diameter in each group is shown. Each marker represents an individual oviduct. The horizontal line distinguishes normal from dilated oviducts. The number of dilated oviducts (numerator) and total number of oviducts examined (denominator) for each group is also shown. Significant (P ≤ 0.05; Fisher's exact test) difference between * live EB i.n. versus BSA i.n., ** live EB i.m. versus BSA i.n., *** i.n live EB versus i.m. live EB. All experiments were repeated twice, and composite results are shown.